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Neurochemical alterations observed with proton magnetic resonance spectroscopy are proportional to the cytosine-thymine-guanine repeat size. Increases in myoinositol and creatine concentrations may be caused by increased glial content,while elevated levels of choline-containing compounds are most likely caused by increased glial content and cell membrane abnormalities.Proton magnetic resonance spectroscopy is a powerful noninvasive tool to study brain biochemistry,which may reflect the extent of neuropathological involvement in patients with myotonic dystrophy. |
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